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As the film ends, on-screen text reveals that the FDA later allowed Woodroof to take peptide T for personal use and that he died of AIDS in 1992, seven years later than his doctors initially predicted.The film is based on the real life of Ron Woodroof, a patient of HIV and AIDS, who was the subject of a lengthy 1992 article in The Dallas Morning News written by journalist and author Bill Minutaglio.

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The judge is compassionate toward him and admonishes the FDA, but lacks the legal tools to do anything.On October 3, 2012, it was announced that Swank had dropped out of the film and that Gael Garcia Bernal was in talks to play an HIV patient who meets Woodroof in the hospital and helps him in the club.When Leto was asked about his role, he said: "This was a really special movie. It's one of the best things I've ever done." He also said that he tried to stay focused on the role because he knew it was an incredible opportunity.When Woodroof has a heart attack caused by a recently acquired dose of interferon, Dr.Sevard learns of the club and the alternative medication.

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